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With this model, various drugs have been evaluated. However, the extensive time period required for disease progression means that the drug is not administered until an end-point disease score has been reached. This can lead to issues with the evaluation of efficacy, particularly for the chronic disease state. A model is required which is fast enough for disease to be evaluated at defined time points without the end-point disease state. Here we describe the effects of the immunosuppressant drugs, cyclophosphamide (Cy), azathioprine (Az) and prednisolone (Pred), in a cohort of MRL-Fas(lpr) mice and compare the results with those of the NZB x NZW model. Mice were treated with either Cy (3 mg/kg), Az (20 mg/kg), Pred (2 mg/kg) or vehicle for 2, 4, 8 and 12 weeks. Mice were then evaluated for signs of disease by using a clinical score system. 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